2 edition of ansport of calcium and magnesium across the placenta of the diabetic rat. found in the catalog.
ansport of calcium and magnesium across the placenta of the diabetic rat.
Shahid Masud Husain
Thesis (M.D.) - University of Manchester, Faculty of Medicine.
|Contributions||University of Manchester. Faculty of Medicine.|
|The Physical Object|
|Number of Pages||215|
Diabetic insults at the beginning of gestation as in many pregestational diabetic pregnancies may have long-term effects on placental development. These adaptive responses of the placenta to the diabetic environment, such as buffering excess maternal glucose or increased vascular resistance, may help limit fetal growth within a normal range. In the diabetic condition, derangement of calcium homeostasis is multifactorial and, although it was reported in that diabetic patients exhibited normal calcium homeostasis, i.e., no change in plasma levels of total and ionized calcium, PTH, 25(OH)D 3, and 1,25(OH) 2 D 3, new investigations in the s mostly found impaired calcium.
Husain SM, Mughal MZ: Mineral transport across the placenta. Arch Dis Child , Stulc J, Stulcova B: Transport of calcium by the placenta of the rat. J Physiol 1, Borke JL, Curide A, Verna AK et al: Calcium pump epitopes in placental trophoblast basal plasma membranes. Am J Physiol C, H Bond's 16 research works with citations and reads, including: Increased maternofetal calcium flux in parathyroid hormone-related protein-null mice.
Type 2 diabetes imposes a major public health burden and disproportionally affects the black population in the United States. 1 Identification of novel factors of diabetes risk may aid etiologic understanding of this highly prevalent disease. Calcium is traditionally thought of in relation to bone health; however, emerging epidemiologic evidence has suggested an association between elevated. Evidence is emerging that the ability of the placenta to supply nutrients to the developing fetus adapts according to fetal demand. To examine this adaptation further, we tested the hypothesis that placental maternofetal transport of calcium adapts according to fetal calcium requirements. We used a mouse model of fetal growth restriction, the placental-specific Igf2 knockout (P0) mouse, shown.
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Background: Offspring of diabetic rats have reduced urinary calcium and magnesium excretion compared with offspring of controls; these differences persist up to16 weeks after birth, a time equivalent to young adulthood in humans.
Objectives: To test the hypothesis that urinary calcium and magnesium excretion would be lower in children born to mothers with insulin dependent diabetes Cited by: 9. Transcellular placental maternofetal flux of calcium and magnesium is reduced in diabetic pregnancy in the rat which might be due to changes in placental cellularity.
In order to investigate this wet and dry weight, DNA and protein content were measured in placentas from untreated diabetic (D O), insulin-treated diabetic (D I) and control rats (C) on day 21 of gestation (term=23 Cited by: 6.
There might be two different transporters at the placenta, one for calcium and one for magnesium; this was previously suggested by Gunther et ai.,18 who postulated the existence of a magnesium transport system separate from the calcium adenosine 5'-triphosphatase system involved with calcium transport.
Cited by: 7. calcium and magnesium across the diabetic rat placenta; the reduced calcium ﬂux can be partly explained by an effect on the expression of placental transport components involved in calcium transfer .
Altered placental histology and cellularity in the presence of maternal diabetes mellitus has been reported in both humans  and rats [13,14].
Calcium and magnesium are both present in the diet and the body at levels much higher than those of trace minerals such as iron. Approximately 99% of the calcium and magnesium in the human body is located in the skeleton.
For many years, women have been advised to increase their calcium intake substantially during pregnancy, and there has been concern that many pregnant women do not ingest.
During pregnancy, calcium is actively transported across the placenta from the maternal circulation to the fetal circulation in late gestation by the syncytiotrophoblast cells (the epithelial layer separating the maternal and fetal circulation)7, 20 ().TRPV6 expression appears to be predominant over the TRPV5 expression.
21 Calcium diffuses across these cells by binding with both calbindin-D9K. A wide range of nutrients (e.g., amino acids, phosphorus, and lactate) are transported across the placenta mediated by secondary active transport, utilizing energy provided by ion gradients such as sodium, chloride, and protons [14–16].
Changes in energy availability or ion gradients can profoundly influence net transfer of substrates. Ramberg CF, Jr, Delivoria-Papadopoulos M, Crandall ED, Kronfeld DS.
Kinetic analysis of calcium transport across the placenta. J Appl Physiol. Nov; 35 (5)– Garel JM, Dumont C. Distribution and inactivation of labeled parathyroid hormone in rat. Research on Calcium and Diabetes Diabetes.
A randomized control trial researched the effect vitamin D and calcium each had independently on prediabetic glucose control.
Participants were assigned to 16 weeks of supplementing with either IU of Vitamin D (or placebo) and/or supplementing with mg of calcium (or placebo.). The mechanism of ossification defects in the offspring of diabetic rats have been explained by two models: The push model suggests insufficient supply of Ca 2+ to the fetus due to excessive Ca 2+ loss in maternal urine or due to decreased capacity of the placenta to transport Ca 2+, while the pull model explains that the demand for Ca 2+ is.
During development, nutrients are transferred mainly across the placenta. It has been calculated that during the last trimester of gestation the daily accretion per kilogram of body weight represents around mg of calcium and 70 mg of phosphorus.
SM Husain, TJ Birdsey, JD Glazier, MZ Mughal, HO Garland, CP SibleyEffect of diabetes mellitus on maternofetal flux of calcium and magnesium and calbindin9K mRNA expression in rat placenta Pediatr Res, 35 (), pp. An average full-term fetus contains_30 g calcium, 20 g phosphorus, and g magnesium.
About 80% of mineral is accreted during the third trimester; calcium transfers at mg/day during the. magnesium in diabetic. retinopathy. 12 Biometals () calcium/magnesium ratio in severe dementia of the Alz- Shumiya cataract rat by the administration of drinking.
S M Husain's 21 research works with citations and reads, including: Placental-specific Igf2 knockout mice exhibit hypocalcemia and adaptive changes in placental calcium transport. Midmolecular fragments of PTHrP stimulated magnesium transport across in situ perfused placentas of fetal lambs [, ].
In contrast, N-terminal and midmolecular forms of PTHrP failed to acutely affect the maternofetal clearance of magnesium in the perfused rat placenta .
The partially purified peptide stimulates calcium transport in the sheep placenta (Rodda et al., ), but its role in human pregnancy remains to be determined. Changes in maternal calcitonin have been reported to be inconsistent (Pitkin et al., ) or increased in early pregnancy and then stable throughout the remainder of pregnancy.
In the rat it was estimated that 92% of the fetal calcium had originated from the maternal diet. In the rabbit during late pregnancy, it was determined that about 24 mg of calcium/fetus/day moved across the placenta as compared with a need of about 13 mg for fetal development.
The mechanism whereby red cells maintain their biconcave shape has been a subject of numerous studies. One of the critical factors for the maintenance of biconcave shape is the level of red cell adenosine triphosphate (ATP) levels.
The interaction of calcium, magnesium and ATP with membrane structural proteins exerts a significant role in the control of shape of human red blood cells. Provision of calcium to the developing fetus is essential for bone mineralization, which, if compromised, may increase the risk of developing osteoporosis later in life (Tobias & Cooper, ).Maximal fetal accretion of calcium occurs over the last third of pregnancy, and in the rat, as in other species, the rise in fetal calcium accretion is exponential over this period (Comar, ).
However, the right amount of calcium can have some beneficial effects on insulin resistance. Researchers typically recommend the same dose of calcium and vitamin D for people with diabetes as what is recommended for most people.
Consider 1, mg of calcium daily with IU of vitamin D, but always talk to your health care provider first.Abstract. The metabolic homeostasis of calcium, phosphorus, and magnesium and mineralization of the skeleton are complex functions that require adequate supply of nutrients, the development of the intestinal absorption process, the interaction of several hormones (such as parathyroid hormone, vitamin D, and calcitonin), and optimum renal and skeletal control.Ramberg CF, Jr, Delivoria-Papadopoulos M, Crandall ED, Kronfeld DS.
Kinetic analysis of calcium transport across the placenta. J Appl Physiol. Nov; 35 (5)– [Google Scholar] Garel JM, Dumont C. Distribution and inactivation of labeled parathyroid hormone in rat fetus. Horm Metab Res. May; 4 (3)–